A major focus of the Medicinal Chemistry Collaborative is “natural products,” the molecules synthesized by plants, fungi, and other natural organisms. To find important examples of how natural products have contributed to medicine, one need look no further than penicillin, a molecule produced by a fungus, that sparked the antibiotic revolution. The applications of our natural products research include discovering new lead compounds for drug development, evaluating the safety and efficacy of traditional herbal medicines, and understanding the role that chemical compounds play in communication between living systems.