Coauthored Publications

2017

Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites.
Noemi D. Paguigan, Mohammed H. Al-Huniti, Huzefa A. Raja, Austin Czarnecki, Joanna E. Burdette, Mariana González-Medina, José L. Medina-Franco, Stephen J. Polyak, Cedric J. Pearce, Mitchell P. Croatt, Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 2017, Article in Press
doi.org/10.1016/j.bmc.2017.07.041

– – –

Plasma Pharmacokinetics and Bioavailability of Verticillin A Following Different Routes of Administration in Mice Using Liquid Chromatography Tandem Mass Spectrometry.
Jiang Wang, Xiaohua Zhu, Shamala Kolli, Hongyan Wang, Cedric J. Pearce, Nicholas H. Oberlies, and Mitch A. Phelps
Journal of Pharmaceutical and Biomedical Analysis, 2017139, 187-192.
PMID: 28284083; PMCID: PMC5399420; doi: 10.1016/j.jpba.2017.02.051

– – –

Safety Assessment of Mushrooms in Dietary Supplements by Combining Analytical Data with in Silico Toxicology Evaluation.
Karen M. VanderMolen, Jason G. Little, Vincent P. Sica, Tamam El-Elimat, Huzefa A. Raja, Nicholas H. Oberlies, Timothy R. Baker, and Catherine Mahony
Food and Chemical Toxicology, 2017103, 133-147.
PMID: 28267567; doi: 10.1016/j.fct.2017.03.005

– – –

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community.
Huzefa A. Raja, Andrew N. Miller, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 201780, 756-770.
PMID: 28199101; PMCID: PMC5368684; doi: 10.1021/acs.jnatprod.6b01085

– – –

DNA Barcoding for Identification of Consumer-Relevant Mushrooms: A Partial Solution for Product Certification?
Huzefa A. Raja, Timothy R. Baker, Jason G. Little, and Nicholas H. Oberlies
Food Chemistry, 2017214, 383-392.
PMID: 27507489; doi: 10.1016/j.foodchem.2016.07.052

– – –

Enhanced Dereplication of Fungal Cultures Via Use of Mass Defect Filtering.
Noemi D. Paguigan, Tamam El-Elimat, Diana Kao, Huzefa A. Raja, Cedric J. Pearce, and Nicholas H. Oberlies
The Journal of Antibiotics, 201770, 553-561.
PMID: 28074050 PMCID; PMC5407915; doi: 10.1038/ja.2016.145

– – –

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.
Chunwan Lu, Amy V. Paschall, Huidong Shi, Natasha Savage, Jennifer L. Waller, Maria E. Sabbatini, Nicholas H. Oberlies, Cedric Pearce, and Kebin Liu
Journal of the National Cancer Institute, 2017109, djw283.
PMID: 28131992 PMCID; PMC5291187; doi: 10.1093/jnci/djw283

– – –

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study.
Kellogg, J. J.; Graf, T. N.; Paine, M. F.; McCune, J. S.; Kvalheim, O. M.; Oberlies, N. H.; Cech, N. B.,
Journal of natural products, 80 (5), 1457-1466.
doi: 10.1021/acs.jnatprod.6b01156

– – –

Scaffold Diversity of Fungal Metabolites.
Mariana González-Medina, John R. Owen, Tamam El-Elimat, Cedric J. Pearce, Nicholas H. Oberlies, Mario Figueroa, and José L. Medina-Franco
Frontiers in Pharmacology, 20178, 180.
PMID: 28420994; PMCID: PMC5376591; doi: 10.3389/fphar.2017.00180

– – –

a-Pyrone Derivatives, Tetra/Hexahydroxanthones, and Cyclodepsipeptides from Two Freshwater Fungi.
Tamam El-Elimat, Huzefa A Raja, Cynthia S. Day, Hana McFeeters, Robert L. McFeeters, and Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 201725, 795-804.
PMID: 27964996; doi: 10.1016/j.bmc.2016.11.059

– – –

Nanoparticle Drug-Delivery Systems for Peritoneal Cancers: A Case Study of the Design, Characterization and Development of the Expansile Nanoparticle.
Aaron H. Colby, Nicholas H. Oberlies, Cedric J. Pearce, Victoria L. M. Herrera, Yolonda L. Colson, and Mark W. Grinstaff
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 20179, e1451-n/a.
PMID: 28185434; PMCID: PMC5389910; doi: 10.1002/wnan.1451

– – –

qNMR for profiling the production of fungal secondary metabolites.
Brooks, W. C.; Paguigan, N. D.; Raja, H. A.; Moy, F. J.; Cech, N. B.; Pearce, C. J.; Oberlies, N. H.
Magnetic resonance in chemistry : MRC, 55 (7), 670-676.
doi: 10.1002/mrc.4571

– – –

Decarboxylative and dehydrative coupling of dienoic acids and pentadienyl alcohols to form 1,3,6,8-tetraenes
Ghina’a I. Abu Deiab, Mohammed H. Al-Huniti, I. F. Dempsey Hyatt, Emma E. Nagy, Kristen E. Gettys, Sommayah S. Sayed, Christine M. Joliat, Paige E. Daniel, Rupa M. Vummalaneni, Andrew T. Morehead Jr, Andrew L. Sargent and Mitchell P. Croatt
Beilstein Journal of Organic Chemistry, 13, 384-392.
PMID: 28382176 PMCID: PMC5355911 DOI: 10.3762/bjoc.13.41

– – –

Structure-Activity Relationships of Benzothiazole GPR35 Antagonists
Manahil M. Abdalhameed, Pingwei Zhao, Dow P. Hurst, Patricia H. Reggio, Mary E. Abood, and Mitchell P. Croatt
Bioorganic & Medicinal Chemistry Letters, 27, 612-615.
doi.org/10.1016/j.bmcl.2016.12.012

– – –

Targeting quorum sensing signal biosynthesis to fight antibiotic resistant infections: Ambuic acid as a model inhibitor.
Daniel A. Todd, C. P. Parlet, H. A. Crosby, C. L. Malone, K. P. Heilmann, Alex R. Horswill, Nadja B. Cech.
Antimicrobial Agents and Chemotherapy, in press
doi:10.1128/AAC.00263-17

– – –

Secondary Metabolites from the leaves of goldenseal (Hydrastis canadensis).
Martha Leyte-Lugo, Emily R. Britton, Daniel H. Foil, Adam R. Brown, Daniel A. Todd, Jose Rivera Chavez, Nicholas H. Oberlies, Nadja B. Cech.
Phytochemistry Letters, 20, 54-60.
doi.org/10.1016/j.phytol.2017.03.012

– – –

Molecular Targets of the Phytocannabinoids: A Complex Picture.
Paula Morales, Dow P. Hurst, Patricia H. Reggio.
Progress in the chemistry of organic natural products, 103, 103-131.
doi: 10.1007/978-3-319-45541-9_4

– – –

A dual substrate kinetic model for cytochrome P450(BM3)-F87G catalysis: simultaneous binding of long chain aldehydes and 4-fluorophenol.
Ledford C, McMahon M, Whitesell A, Khan G, Kandagatla SK, Hurst DP, Reggio PH, Raner GM.
Biotechnol Lett., 2017 Feb;39(2):311-321.
PMID: 27864654; doi: 10.1007/s10529-016-2252-7

– – –

Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor.
Lingerfelt MA, Zhao P, Sharir HP, Hurst DP, Reggio PH, Abood ME.
Biochemistry., 2017 Jan 24;56(3):473-486.
PMID: 28005346; PMCID: PMC5338039; doi:10.1021/acs.biochem.6b01013

 

2016

Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition.
Todd, D. A.; Zich, D. B.; Ettefagh, K. A.; Kavanaugh, J. S.; Horswill, A. R.; Cech, N. B.,
Journal of microbiological methods, 127, 89-94.
doi: 10.1016/j.mimet.2016.05.024

Spatial and Temporal Profiling of Griseofulvin Production in Xylaria cubensis Using Mass Spectrometry Mapping.
Vincent Sica, Evan Rees, Edem Tchegnon, Robert Bardsley, Huzefa Raja, and Nicholas Oberlies
Frontiers in Microbiology, 20167.
PMID: 27199902; PMCID: PMC4844619; doi: 10.3389/fmicb.2016.00544

Optimizing Production and Evaluating Biosynthesis in Situ of a Herbicidal Compound, Mevalocidin, from Coniolariella Sp.
Vincent P. Sica, Mario Figueroa, Huzefa A. Raja, Tamam El-Elimat, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Industrial Microbiology & Biotechnology, 201643, 1149-1157.
PMID: 27221133; doi: 10.1007/s10295-016-1782-2

Acetophenone Derivatives from a Freshwater Fungal Isolate of Recently Described Lindgomyces Madisonensis (G416).
Noemi D. Paguigan, Huzefa A. Raja, Cynthia S. Day, and Nicholas H. Oberlies
Phytochemistry, 2016126, 59-65.
PMID: 26988728; doi: 10.1016/j.phytochem.2016.03.007

Discovery of Anticancer Agents of Diverse Natural Origin.
Douglas Kinghorn, Esperanza J. Carcache De Blanco, David M. Lucas, H. Liva Rakotondraibe, Jimmy Orjala, D. Doel Soejarto, Nicholas H. Oberlies, Cedric J. Pearce, Mansukh C. Wani, Brent R. Stockwell, Joanna E. Burdette, Steven M. Swanson, James R. Fuchs, Mitchell A. Phelps, Lihui Xu, Xiaoli Zhang, and Young Yongchun Shen
Anticancer Research, 201636, 5623-5637.
PMID: 27793884; PMCID: PMC5098703; doi: 10.21873/anticanres.11146

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds.
Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, and Nadja B. Cech
Journal of Natural Products, 201679, 376-386.
PMID: 26841051; doi: 10.1021/acs.jnatprod.5b01014

Talarolutins A–D: Meroterpenoids from an Endophytic Fungal Isolate of Talaromyces minioluteus.
Amninder Kaur, Huzefa A. Raja, Dale C. Swenson, Rajesh Agarwal, Gagan Deep, Joseph O. Falkinham III, and Nicholas H. Oberlies
Phytochemistry, 2016126, 4-10.
PMID: 27048854; PMCID: PMC4861051; doi: 10.1016/j.phytochem.2016.03.013

Pannorin B, a New Naphthopyrone from an Endophytic Fungal Isolate of Penicillium Sp.
Amninder Kaur, Huzefa A. Raja, Gagan Deep, Rajesh Agarwal, and Nicholas H. Oberlies
Magnetic Resonance in Chemistry, 2016, 54, 164-167.
PMID: 26365944; doi: 10.1002/mrc.4324

Secondary Metabolites from Fungal Endophytes of Echinacea purpurea Suppress Cytokine Secretion by Macrophage-Type Cells.
Amninder Kaur, Martina Oberhofer, Monika Juzumaite, Huzefa A. Raja, Travis V. Gulledge, Diana Kao, Stanley H. Faeth, Scott M. Laster, Nicholas H. Oberlies, and Nadja B. Cech
Natural Product Communications, 201611, 1143-1146.
PMID: 28479944

Comparison of electrospray ionization and atmospheric pressure photoionization liquid chromatography mass spectrometry methods for analysis of ergot alkaloids from endophyte-infected sleepygrass (Achnatherum robustum). Jarmusch, A. K.; Musso, A. M.; Shymanovich, T.; Jarmusch, S. A.; Weavil, M. J.; Lovin, M. E.; Ehrmann, B. M.; Saari, S.; Nichols, D. E.; Faeth, S. H.; Cech, N. B.
Journal of pharmaceutical and biomedical analysis, 117, 11-7.
doi: 10.1016/j.jpba.2015.08.031

A Validated UHPLC-Tandem Mass Spectrometry Method for Quantitative Analysis of Flavonolignans in Milk Thistle (Silybum marianum) Extracts.
Tyler N. Graf, Nadja B. Cech, Stephen J. Polyak, and Nicholas H. Oberlies
Journal of Pharmaceutical and Biomedical Analysis, 2016126, 26-33.
PMID: 27136284; PMCID: PMC4893890; doi: 10.1016/j.jpba.2016.04.028

Chemoinformatic Expedition of the Chemical Space of Fungal Products.
Mariana González-Medina, Fernando D. Prieto-Martínez, J. Jesús Naveja, Oscar Méndez-Lucio, Tamam El-Elimat, Cedric J. Pearce, Nicholas H. Oberlies, Mario Figueroa, and José L. Medina-Franco
Future Medicinal Chemistry, 20168, 1399-1412.
PMID: 27485744; doi: 10.4155/fmc-2016-0079

A Review of the Medicinal Uses and Pharmacology of Ashitaba.
Caesar, L. K.; Cech, N. B.
Planta medica, 82 (14), 1236-45.
doi: 10.1055/s-0042-110496

qNMR for profiling the production of fungal secondary metabolites.
Brooks, W. C.; Paguigan, N. D.; Raja, H. A.; Moy, F. J.; Cech, N. B.; Pearce, C. J.; Oberlies, N. H.
Magnetic resonance in chemistry : MRC, 55 (7), 670-676.
doi: 10.1002/mrc.4571

Design, Synthesis, and Analysis of Antagonists of GPR55:  Piperidine-Substituted 1,3,4-oxadiazol-2-ones
Maria Elena Meza-Avina, Mary A. Lingerfelt, Linda Console-Bram, Thomas F. Gamage, Haleli Sharir, Kristen E. Gettys, Dow P. Hurst, Evangelia Kotsikorou, Derek M Shore, Marc G. Caron, Narasinga Rao, Larry S. Barak, Mary E Abood, Patricia H. Reggio, and Mitchell P Croatt
Bioorganic & Medicinal Chemistry Letters 201626, 1827-1830.
http://www.sciencedirect.com/science/article/pii/S0960894X16301421

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis).
Joseph M. Egan, Amninder Kaur, Huzefa A. Raja, Joshua J. Kellogg, Nicholas H. Oberlies, Nadja B. Cech.
Phytochemistry Letters, 17, 219-225.
doi.org/10.1016/j.phytol.2016.07.031

One for the Price of Two…Are Bivalent Ligands Targeting Cannabinoid Receptor Dimers Capable of Simultaneously Binding to both Receptors?
Glass M, Govindpani K, Furkert DP, Hurst DP, Reggio PH, Flanagan JU.
Trends Pharmacol Sci., 2016 May;37(5):353-63.
PMID: 26917061; doi: 10.1016/j.tips.2016.01.010

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch D, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly ME, Denovan-Wright EM, Thakur GA.
ACS Chem Neurosci., 2016 Jun 15;7(6):776-98.
PMID: 27046127; PMCID: PMC5358098; doi: 10.1021/acschemneuro.6b00041

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.
Morales P, Gómez-Cañas M, Navarro G, Hurst DP, Carrillo-Salinas FJ, Lagartera L, Pazos R, Goya P, Reggio PH, Guaza C, Franco R, Fernández-Ruiz J, Jagerovic N.
J Med Chem., 2016 Jul 28;59(14):6753-71.
PMID: 27309150; PMCID: PMC5321205; doi: 10.1021/acs.jmedchem.6b00397

2015

Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria.
Daniel A. Todd, Travis V. Gulledge, Emily R. Britton, Martina Oberhofer, Martha Leyte-Lugo, Ashley N. Moody, Tatsiana Shymanovich, Laura F. Grubbs, Monika Juzumaite, Tyler N. Graf, Nicholas H. Oberlies, Stanley H. Faeth, Scott M. Laster, and Nadja B. Cech
Plos One, 201510, e0124276.
PMID: 25933416; doi: 10.1371/journal.pone.0124276

Spiroscytalin, a New Tetramic Acid and Other Metabolites of Mixed Biogenesis fromScytalidium cuboideum.
Arlene A. Sy-Cordero, Mario Figueroa, Huzefa A. Raja, Maria Elena Meza Aviña, Mitchell P. Croatt, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Tetrahedron, 2015, 71, 8899-8904.
PMID: 26525642; PMCID: PMC4624200; doi: 10.1016/j.tet.2015.09.073

Dereplicating and Spatial Mapping of Secondary Metabolites from Fungal Cultures in Situ.
Vincent P .Sica, Huzefa A. Raja, Tamam El-Elimat, Vilmos Kertesz, Gary J.Van Berkel, Cedric J.Pearce, and Nicholas H.Oberlies
Journal of Natural Products, 2015, 78, 1926-1936.
PMID: 26192135; PMCID: PMC4570219; doi: 10.1021/acs.jnatprod.5b00268

Alkaloid variation among epichloid endophytes of sleepygrass (Achnatherum robustum) and consequences for resistance to insect herbivores.
Shymanovich, T.; Saari, S.; Lovin, M. E.; Jarmusch, A. K.; Jarmusch, S. A.; Musso, A. M.; Charlton, N. D.; Young, C. A.; Cech, N. B.; Faeth, S. H.
Journal of chemical ecology, 41 (1), 93-104.
doi: 10.1007/s10886-014-0534-x

Phylogenetic and Chemical Diversity of Fungal Endophytes Isolated from Silybum marianum(L) Gaertn. (Milk Thistle).
Huzefa A. Raja, Amninder Kaur, Tamam El-Elimat, Mario Figueroa, Rahul Kumar, Gagan Deep, Rajesh Agarwal, Stanley H. Faeth, Nadja B. Cech, and Nicholas H. Oberlies
Mycology, 20156, 8-27.
doi:10.1080/21501203.2015.1009186

Minutisphaerales (Dothideomycetes, Ascomycota): A New Order of Freshwater Ascomycetes Including a New Family, Minutisphaeraceae, and Two New Species from North Carolina, USA.
Huzefa A. Raja, Tamam El-Elimat, Nicholas H. Oberlies, Carol A. Shearer, Andrew N. Miller, Kazuaki Tanaka, Akira Hashimoto, and Jacques Fournier
Mycologia, 2015, 107, 845-862.
PMID: 26315030; doi: 10.3852/15-013

H3K9 Trimethylation Silences FASs Expression to Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.
Amy V. Paschall, Dafeng Yang, Chunwan Lu, Jeong-Hyeon Choi, Xia Li, Feiyan Liu, Mario Figueroa, Nicholas H. Oberlies, Cedric Pearce, Wendy B. Bollag, Asha Nayak-Kapoor, and Kebin Liu
The Journal of Immunology, 2015, 195, 1868-1882.
PMID: 26136424; PMCID: PMC4530033; doi: 10.4049/jimmunol.1402243

New Diketopiperazine Dimer from a Filamentous Fungal Isolate of Aspergillus sydowii.
Amninder Kaur, Huzefa A. Raja, Blaise A. Darveaux, Wei-Lun Chen, Steven M. Swanson, Cedric J. Pearce, and Nicholas H. Oberlies
Magnetic Resonance in Chemistry, 2015, 53, 616-619.
PMID: 26040447; PMCID: PMC4692248; doi: 10.1002/mrc.4254

Chemoenzymatic Synthesis, Characterization, and Scale-up of Milk Thistle Flavonolignan Glucuronides.
Brandon T. Gufford, Tyler N. Graf, Noemi D. Paguigan, Nicholas H. Oberlies, and Mary F. Paine
Drug Metabolism and Disposition, 2015, 43, 1734-1743.
PMID: 26316643; PMCID: PMC4613946; doi: 10.1124/dmd.115.066076

Isolation, Semisynthesis, Covalent Docking and Transforming Growth Factor Beta-Activated Kinase 1 (TAK1)-Inhibitory Activities of (5Z)-7-Oxozeaenol Analogues.
Lara Fakhouri, Tamam El-Elimat, Dow P. Hurst, Patricia H. Reggio, Cedric J. Pearce, Nicholas H. Oberlies, and Mitchell P. Croatt
Bioorganic & Medicinal Chemistry, 2015, 23, 6993-6999.
PMID: 26481152; PMCID: PMC4661079; doi: 10.1016/j.bmc.2015.09.037

Sorbicillinoid Analogs with Cytotoxic and Selective Anti-Aspergillus Activities fromScytalidium album.
Tamam El-Elimat, Huzefa A. Raja, Mario Figueroa, Steven M. Swanson, Joseph O. Falkinham III, David M. Lucas, Michael R. Grever, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
The Journal of Antibiotics, 201568, 191-196.
PMID: 25248727; PMCID: PMC4372511; doi: 10.1038/ja.2014.125

Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.
Tamam El-Elimat, Mario Figueroa, Huzefa A. Raja, Tyler N. Graf, Steven M. Swanson, Joseph O. Falkinham, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
European Journal of Organic Chemistry, 20152015, 109-121.
PMID: 25574154; PMCID: PMC4283843; doi: 10.1002/ejoc.201402984

omega-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.
Daly, S. M.; Elmore, B. O.; Kavanaugh, J. S.; Triplett, K. D.; Figueroa, M.; Raja, H. A.; El-Elimat, T.; Crosby, H. A.; Femling, J. K.; Cech, N. B.; Horswill, A. R.; Oberlies, N. H.; Hall, P. R.
Antimicrobial agents and chemotherapy, 59 (4), 2223-35.
doi: 10.1128/aac.04564-14

Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica).
Bussey, R. O., 3rd; Kaur, A.; Todd, D. A.; Egan, J. M.; El-Elimat, T.; Graf, T. N.; Raja, H. A.; Oberlies, N. H.; Cech, N. B.
Phytochemistry letters, 11, 202-208.
doi: 10.1016/j.phytol.2014.12.013

A mass spectrometry-based assay for improved quantitative measurements of efflux pump inhibition.
Brown, A. R.; Ettefagh, K. A.; Todd, D.; Cole, P. S.; Egan, J. M.; Foil, D. H.; Graf, T. N.; Schindler, B. D.; Kaatz, G. W.; Cech, N. B.
PloS one, 10 (5), e0124814.
doi: 10.1371/journal.pone.0124814

A new mass spectrometry based bioassay for the direct assessment of hyaluronidase activity and inhibition.
Britton, E. R.; Ibberson, C. B.; Horswill, A. R.; Cech, N. B.
Journal of microbiological methods, 119, 163-7.
dopi: 10.1016/j.mimet.2015.10.019

Cytokine-suppressive activity of a hydroxylated alkylamide from Echinacea purpurea.
Martha Leyte-Luge, Daniel A. Todd, Tyler V. Gulledge, Emily R. Britton, Monika Juzumaite, Fred S. Carter, Scott M. Laster, Nadja B. Cech.
Planta Medica Letters, 2, e25-e27.
doi: 10.1055/s-0035-1557764

(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)(cyclohexyl)methanone hydrochloride (LDK1229): a new cannabinoid CB1 receptor inverse agonist from the class of benzhydryl piperazine analogs. Mol Pharmacol.
Mahmoud MM, Olszewska T, Liu H, Shore DM, Hurst DP, Reggio PH, Lu D, Kendall DA.
Mol Pharmacol., 2015 Feb;87(2):197-206.
PMID: 25411367; PMCID: PMC4293445; doi: 10.1124/mol.114.095471

Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols.
Nikas SP, Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, Makriyannis A.
J Med Chem., 2015 Jan 22;58(2):665-81.
PMID: 25470070; PMCID: PMC4306527; doi:10.1021/jm501165d

Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.
Janero DR, Yaddanapudi S, Zvonok N, Subramanian KV, Shukla VG, Stahl E, Zhou L, Hurst D, Wager-Miller J, Bohn LM, Reggio PH, Mackie K, Makriyannis A.
ACS Chem Neurosci., 2015 Aug 19;6(8):1400-10.
PMID: 25978068; PMCID: PMC4804703; doi: 10.1021/acschemneuro.5b00090

Synthesis, pharmacological evaluation and docking studies of pyrrole structure-based CB2 receptor antagonists.
Ragusa G, Gómez-Cañas M, Morales P, Hurst DP, Deligia F, Pazos R, Pinna GA, Fernández-Ruiz J, Goya P, Reggio PH, Jagerovic N, García-Arencibia M, Murineddu G.
Eur J Med Chem., 2015 Aug 28;101:651-67.
PMID: 26209834; doi: 10.1016/j.ejmech.2015.06.057

Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.
Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, Spanagel R.
J Neurosci., 2015 Oct 14;35(41):13975-88.
PMID: 26468198; PMCID: PMC4604232; doi: 10.1523/JNEUROSCI.1937-15.2015

2014

Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite.
Karen M. VanderMolen, Blaise A. Darveaux, Wei-Lun Chen, Steven M. Swanson, Cedric J. Pearce, and Nicholas H. Oberlies
RSC advances, 20144, 18329-18335.
PMID: 24955237; PMCID: PMC4061710; doi: 10.1039/c4ra00274a

CodY-mediated regulation of the Staphylococcus aureus Agr system integrates nutritional and population density signals.
Roux, A.; Todd, D. A.; Velazquez, J. V.; Cech, N. B.; Sonenshein, A. L.,
Journal of bacteriology, 196 (6), 1184-96.
doi: 10.1128/jb.00128-13

Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization. Olson, M. E.; Todd, D. A.; Schaeffer, C. R.; Paharik, A. E.; Van Dyke, M. J.; Buttner, H.; Dunman, P. M.; Rohde, H.; Cech, N. B.; Fey, P. D.; Horswill, A. R.,
Journal of bacteriology, 196 (19), 3482-93.
doi: 10.1128/jb.01882-14

Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation.
Brandon T. Gufford, Gang Chen, Philip Lazarus, Tyler N. Graf, Nicholas H. Oberlies, and Mary F. Paine
Drug Metabolism and Disposition, 201442, 1675-1683.
PMID: 25008344; PMCID: PMC4164973; doi: 10.1124/dmd.114.059451

Polyhydroxyanthraquinones as Quorum Sensing Inhibitors from the Guttates of Penicilliumrestrictum and Their Analysis by Desorption Electrospray Ionization Mass Spectrometry.
Mario Figueroa, Alan K. Jarmusch, Huzefa A. Raja, Tamam El-Elimat, Jeffrey S. Kavanaugh, Alexander R. Horswill, R. Graham Cooks, Nadja B. Cech, and Nicholas H. Oberlies
Journal of Natural Products, 201477, 1351-1358.
PMID: 24911880; PMCID: PMC4073659; doi: 10.1021/np5000704

Flavonolignans from Aspergillus iizukae, a Fungal Endophyte of Milk Thistle (Silybum marianum).
Tamam El-Elimat, Huzefa A. Raja, Tyler N. Graf, Stanley H. Faeth, Nadja B. Cech, and Nicholas H. Oberlies
Journal of Natural Products, 201477, 193-199.
PMID: 24456525; doi: 10.1021/np400955q

Isochromenones, Isobenzofuranone, and Tetrahydronaphthalenes Produced by Paraphoma radicina, a Fungus Isolated from a Freshwater Habitat.
Tamam El-Elimat, Huzefa A. Raja, Mario Figueroa, Joseph O. Falkinham III, and Nicholas H. Oberlies
Phytochemistry, 2014104, 114-120.
PMID: 24833033; doi: 10.1016/j.phytochem.2014.04.006

Greensporones: Resorcylic Acid Lactones from an Aquatic Halenospora Sp.
Tamam El-Elimat, Huzefa A. Raja, Cynthia S. Day, Wei-Lun Chen, Steven M. Swanson, and Nicholas H. Oberlies
Journal of Natural Products, 2014, 77, 2088-2098.
PMID: 25093280; PMCID: PMC4176394; doi: 10.1021/np500497r

Antimycobacterial Furofuran Lignans from the Roots of Anemopsis californica.
Robert O. Bussey III, Arlene A. Sy-Cordero, Mario Figueroa, Fredrick S. Carter, Joseph O. Falkinham III, Nicholas H. Oberlies, and Nadja B. Cech
Planta Medica, 201480, 498-501.
PMID: 24687738; doi: 10.1055/s-0034-1368352

Investigations of analyte-specific response saturation and dynamic range limitations in atmospheric pressure ionization mass spectrometry.
Alfaro, C. M.; Uwakweh, A. O.; Todd, D. A.; Ehrmann, B. M.; Cech, N. B.
Analytical chemistry, 86 (21), 10639-45.
doi: 10.1021/ac502984a

Investigations of analyte-specific response saturation and dymanic range limitations in atmospheric pressure ionization mass spectrometry.
Clint Alfaro, Agbo-Oma Uwakweh, Daniel A. Todd, Brandie M. Ehrmann, Nadja B. Cech.
Analytical Chemistry86, (21), 10639-10645.
PMID:25268329; doi: 10.1021/ac502984a

Structural Basis of G Protein-Coupled Receptor-Gi Protein Interaction: Formation of the Cannabinoid CB2 Receptor/Gi Complex.
S. Mnpotra, Z. Qiao, J. Cai, D. L. Lynch, A. Grossfield, N. Leioatts, D. P. Hurst, M.C. Pitman, Z-H. Song,  P.H. Reggio.
Biol. Chem., 2014 Jul 18;289(29):20259-72.
PMID: 24855641; PMCID: PMC4106340; doi: 10.1074/jbc.M113.539916

Crucial positively charged residues for ligand activation of the GPR35 receptor.
Zhao P, Lane TR, Gao HG, Hurst DP, Kotsikorou E, Le L, Brailoiu E, Reggio PH, Abood ME.
J Biol Chem., 289(6):3625-38.
PMID: 24347166; PMCID: PMC3916562; doi: 10.1074/jbc.M113.508382

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling.
Shore DM, Baillie GL, Hurst DH, Navas F 3rd, Seltzman HH, Marcu JP, Abood ME, Ross RA, Reggio PH.
Biol Chem., 289(9):5828-45.
PMID: 24366865; PMCID: PMC3937654; doi: 10.1074/jbc.M113.478495

Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.
Science, 2014 Jan 3;343(6166):94-8.
PMID: 24385629; PMCID: PMC4057431; doi: 10.1126/science.1243985

CB2-selective cannabinoid receptor ligands: synthesis, pharmacological evaluation, and molecular modeling investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides.
Lucchesi V, Hurst DP, Shore DM, Bertini S, Ehrmann BM, Allarà M, Lawrence L, Ligresti A, Minutolo F, Saccomanni G, Sharir H, Macchia M, Di Marzo V, Abood ME, Reggio PH, Manera C.
J Med Chem., 2014 Nov 13;57(21):8777-91.
PMID: 25272206; PMCID: PMC4234427; doi: 10.1021/jm500807e

Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.
Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K.
Proteins. 2014 Mar;82(3):452-65.
PMID: 23999926; PMCID: PMC4071771; doi: 10.1002/prot.24411

2013

Evaluation of Culture Media for the Production of Secondary Metabolites in a Natural Products Screening Program.
Karen M. VanderMolen, Huzefa A. Raja, Tamam El-Elimat, and Nicholas H. Oberlies
AMB Express, 20133, 71.
PMID: 24342059; PMCID: PMC3917616; doi: 10.1186/2191-0855-3-71

Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice Using Ultra-Performance Liquid Chromatography.
Karen M. VanderMolen, Nadja B. Cech, Mary F. Paine, and Nicholas H. Oberlies
Phytochemical Analysis, 201324, 654-660.
PMID: 23780830; PMCID: PMC3855432; doi: 10.1002/pca.2449

Enhanced Bioactivity of Silybin B Methylation Products.
Arlene A. Sy-Cordero, Tyler N. Graf, Scott P. Runyon, Mansukh C. Wani, David J. Kroll, Rajesh Agarwal, Scott J. Brantley, Mary F. Paine, Stephen J. Polyak, and Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 201321, 742-747.
PMID: 23260576; PMCID: PMC3630461; doi: 10.1016/j.bmc.2012.11.035

Freshwater Ascomycetes: Minutisphaera (Dothideomycetes) revisited, including one new species from Japan.
Huzefa Raja, Kazuaki Tanaka, Kazuyuki Hirayama, Akira Hoshimoto, Nicholas H. Oberlies, Mario Figueroa, Andrew N. Miller, Steven E. Zelski, and Carol A. Shearer.
Mycologia, 2013, 105, 959-976.
PMID: 23709484; doi: 10.3852/12-313

Quantitative analysis of autoinducing peptide I (AIP-I) from Staphylococcus aureus cultures using ultrahigh performance liquid chromatography-high resolving power mass spectrometry.
Junio, H. A.; Todd, D. A.; Ettefagh, K. A.; Ehrmann, B. M.; Kavanaugh, J. S.; Horswill, A. R.; Cech, N. B.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 930, 7-12.
doi: 10.1016/j.jchromb.2013.04.019

Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria Sp. (MSX 47401).
Mario Figueroa, Huzefa Raja, Joseph O. Falkinham, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 201376, 1007-1015.
PMID: 23806109; PMCID: PMC3736820; doi: 10.1021/np3008842

Benzoquinones and Terphenyl Compounds as Phosphodiesterase-4B Inhibitors from a Fungus of the Order Chaetothyriales (MSX 47445).
Tamam El-Elimat, Mario Figueroa, Huzefa A. Raja, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Cynthia S. Day, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2013, 76, 382-387.
PMID: 23301853; PMCID: PMC3606633; doi: 10.1021/np300749w

Waol A, Trans-Dihydrowaol A, and Cis-Dihydrowaol A: Polyketide-Derived Γ-Lactones from aVolutella Species.
Tamam El-Elimat, Mario Figueroa, Huzefa A. Raja, Audrey F. Adcock, David J. Kroll, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Tetrahedron Letters, 201354, 4300-4302.
PMID: 23956472; PMCID: PMC3743556; doi: 10.1016/j.tetlet.2013.06.008

A High-Resolution Ms, Ms/Ms, and UV Database of Fungal Secondary Metabolites as a Dereplication Protocol for Bioactive Natural Products.
Tamam El-Elimat, Mario Figueroa, Brandie M. Ehrmann, Nadja B. Cech, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 201376, 1709-1716.
PMID: 23947912; PMCID: PMC3856222; doi: 10.1021/np4004307

A Systematic Approach to Evaluate Herb-Drug Interaction Mechanisms: Investigation of Milk Thistle Extracts and Eight Isolated Constituents as CYP3A Inhibitors.
Scott J. Brantley, Tyler N. Graf, Nicholas H. Oberlies, and Mary F. Paine
Drug Metabolism and Disposition, 201341, 1662-1670.
PMID: 23801821; PMCID: PMC3876807; doi: 10.1124/dmd.113.052563

Sarothrin from Alkanna Orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor.
Jessica R. Bame, Tyler N. Graf, Hiyas A. Junio, R. Owen Bussey, Scott A. Jarmusch, Tamam El-Elimat, Joseph O. Falkinham, Nicholas H. Oberlies, Richard A. Cech, and Nadja B. Cech
Planta Medica, 201379, 327-329.
PMID: 23468310; doi: 10.1055/s-0032-1328259

Mechanistic Study of the Biomimetic Synthesis of Flavonolignan Diastereoisomers in Milk Thistle.
Hanan S. Althagafy, Maria Elena Meza-Aviña, Nicholas H. Oberlies, and Mitchell P. Croatt
The Journal of Organic Chemistry, 201378, 7594-7600.
PMID: 23876147; PMCID: PMC3855429; doi: 10.1021/Jo401137

Semisynthesis, Cytotoxicity, Antiviral Activity, and Drug Interaction Liability of 7-O-Methylated Analogues of Flavonolignans from Milk Thistle.
Hanan S. Althagafy, Tyler N. Graf, Arlene A. Sy-Cordero, Brandon T. Gufford, Mary F. Paine, Jessica Wagoner, Stephen J. Polyak, Mitchell P. Croatt, and Nicholas H. Oberlies
Bioorganic & Medicinal Chemistry, 2013, 21, 3919-3926.
PMID: 23673225; PMCID: PMC3855444; doi: 10.1016/j.bmc.2013.04.017

Identification of the GPR55 Antagonist Binding Site Using a Novel Set of High-Potency GPR55 Selective Ligands
Evangelia Kotsikorou, Haleli Sharir, Derek M Shore, Dow P. Hurst, Diane L. Lynch, Karla E. Madrigal, Susanne Heynen-Genel, Loribelle B. Milan, Thomas D.Y. Chung, Herbert H. Seltzman, Yushi Bai, Marc G. Caron, Lawrence S. Barak, Mitchell P Croatt, Mary E Abood, and Patricia H. Reggio
Biochemistry 2013, 52, 9456-9469.
http://pubs.acs.org/doi/abs/10.1021/bi4008885

The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimet hylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).
Kotsikorou E, Navas F 3rd, Roche MJ, Gilliam AF, Thomas BF, Seltzman HH, Kumar P, Song ZH, Hurst DP, Lynch DL, Reggio PH.
J Med Chem., 2013 Sep 12;56(17):6593-612.
PMID: 23855811; PMCID: PMC3804063; doi: 10.1021/jm400070u

Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and  molecular dynamics simulations.
Hurst DP, Schmeisser M, Reggio PH.
Chem Phys Lipids., 2013 Apr;169:46-56.
PMID: 23485612; PMCID: PMC4034697; doi: 10.1016/j.chemphyslip.2013.01.009

2012

Revisiting the Enniatins: A Review of Their Isolation, Biosynthesis, Structure Determination and Biological Activities.
Arlene A. Sy-Cordero, Cedric J. Pearce, and Nicholas H. Oberlies.
Journal of Antibiotics, 201265, 541-549.
PMID: 22990381; doi: 10.1038/ja.2012.71

Use of the Hollow Fiber Assay for the Discovery of Novel Anticancer Agents from Fungi.
Cedric J. Pearce, Daniel D. Lantvit, Qi Shen, David Jarjoura, Xiaoli Zhang, Nicholas H. Oberlies, David J. Kroll, Mansukh C. Wani, Jimmy Orjala, Djaja D. Soejarto, Norman R. Farnsworth, Esperanza J. Carcache Blanco, James R. Fuchs, A. Douglas Kinghorn, and Steven M. Swanson.
Methods in Molecular Biology 2012, 944, 267-277.
PMID: 23065624; doi: 10.1007/978-1-62703-122-6_20

Cytotoxic Epipolythiodioxopiperazine Alkaloids from Filamentous Fungi of the Bionectriaceae.
Mario Figueroa, Tyler N. Graf, Sloan Ayers, Audrey F. Adcock, David J. Kroll, Jilai Yang, Steven M. Swanson, Ulyana Munoz-Acuna, Esperanza J. Carcache de Blanco, Rajesh Agrawal, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies.
Journal of Antibiotics, 201265, 559-564.
PMID: 22968289; doi: 10.1038/ja.2012.69

Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.
Tamam El-Elimat, Xiaoli Zhang, David Jarjoura, Franklin J. Moy, Jimmy Orjala, A. Douglas Kinghorn, Cedric J. Pearce, and Nicholas H. Oberlies
ACS Medicinal Chemistry Letters, 20123, 645-649.
PMID: 22993669; PMCID: PMC3443637; doi: 10.1021/ml300105s

Cytotoxic Xanthone-Anthraquinone Heterodimers from an Unidentified Fungus of the Order Hypocreales (MSX 17022).
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Susan Matthew, Esperanza J. Carcache de Blanco, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2012, 65, 3-8.
PMID: 22068158; doi: 10.1038/ja.2011.95

Peptaibols from Two Unidentified Fungi of the Order Hypocreales with Cytotoxic, Antibiotic, and Anthelmintic Activities.
Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Joseph O. Falkinham, Mansukh C. Wani, Sheila M. Mitchell, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Peptide Science, 201218, 500-510.
PMID: 22744757; PMCID: PMC3494480; doi: 10.1002/psc.2425

Effects of (5z)-7-Oxozeaenol on MDA-MB-231 Breast Cancer Cells.
Ulyana Muñoz Acuña, Jennifer Wittwer, Sloan Ayers, Cedric J. Pearce, Nicholas H. Oberlies, and Esperanza J. Carcache de Blanco
Anticancer Research, 201232, 2415-2421.
PMID: 22753698; http://ar.iiarjournals.org/content/32/7/2415.abstract

Effects of (5z)-7-Oxozeaenol on the Oxidative Pathway of Cancer Cells.
Ulyana Muñoz Acuña, Jennifer Wittwer, Sloan Ayers, Cedric J. Pearce, Nicholas H. Oberlies, and Esperanza J. Carcache de Blanco
Anticancer Research, 201232, 2665-2671.
PMID: 22753724; http://ar.iiarjournals.org/content/32/7/2665.abstract

Chromenopyrazoles: non-psychoactive and  selective CB cannabinoid agonists with peripheral antinociceptive properties.
Cumella J, Hernández-Folgado L, Girón R, Sánchez E, Morales P, Hurst DP, Gómez-Cañas M, Gómez-Ruiz M, Pinto DC, Goya P, Reggio PH, Martin MI, Fernández-Ruiz J, Silva AM, Jagerovic N.
ChemMedChem., 2012 Mar 5;7(3):452-63.
PMID: 22302767; PMCID: PMC4049093; doi: 10.1002/cmdc.201100568

2011

Romidepsin (Istodax, NSC 630176, FR901228, FK228, Depsipeptide): A Natural Product Recently Approved for Cutaneous T-Cell Lymphoma.
Karen M. VanderMolen, William McCulloch, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2011, 64, 525-531.
PMID: 21587264; PMCID: PMC3163831; doi: 10.1038/ja.2011.35

Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320).
Arlene A. Sy-Cordero, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 2137-2142.
PMID:21978324; doi: 10.1021/np2004243

Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite.
Cherilyn R. Strader, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 900-907.
PMID:21456524; doi: 10.1021/np2000528

Isolation and Identification of Intestinal CYP3A Inhibitors from Cranberry (Vaccinium macrocarpon) Using Human Intestinal Microsomes.
Eunkyung Kim, Arlene Sy-Cordero, Tyler N. Graf, Scott J. Brantley, Mary F. Paine, and Nicholas H. Oberlies
Planta Medica, 2011, 77, 265-270.
PMID:20717876; PMCID: PMC3023844; doi: 10.1055/s-0030-1250259

Synergy-Directed Fractionation of Botanical Medicines: A Case Study with Goldenseal (Hydrastis canadensis).
Hiyas A. Junio, Arlene A. Sy-Cordero, Keivan A. Ettefagh, Johnna T. Burns, Kathryn T. Micko, Tyler N. Graf, Scott J. Richter, Robert E. Cannon, Nicholas H. Oberlies, and and Nadja B. Cech
Journal of Natural Products, 2011, 74, 1621-1629.
PMID:21661731; PMCID: PMC3142294; doi: 10.1021/np200336g

Obionin B: An O-Pyranonaphthoquinone Decaketide from an Unidentified Fungus (MSX 63619) from the Order Pleosporales.
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Blaise A. Darveaux, Cedric J. Pearce, and Nicholas H. Oberlies
Tetrahedron Letters, 2011, 52, 5128-5230.
PMID:22025810; PMCID: PMC3183506; doi: 10.1016/j.tetlet.2011.07.102

Resorcylic Acid Lactones with Cytotoxic and NF-kB Inhibitory Activities and Their Structure-Activity Relationships.
Sloan Ayers, Tyler N. Graf, Audrey F. Adcock, David J. Kroll, Susan Matthew, Esperanza J. Carcache de Blanco, Qi Shen, Steven M. Swanson, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Natural Products, 2011, 74, 1126-1131.
PMID:21513293; PMCID: PMC3111092; doi: 10.1021/np200062x

Thielavin B Methyl Ester: A Cytotoxic Benzoate Trimer from an Unidentified Fungus (MSX 55526) from the Order Sordariales.
Sloan Ayers, Brandie M. Ehrmann, Audrey F. Adcock, David J. Kroll, Mansukh C. Wani, Cedric J. Pearce, and Nicholas H. Oberlies
Tetrahedron Letters, 2011, 52, 5733-5735.
doi: 10.1016/j.tetlet.2011.08.125

2010

Dereplication of Macrocyclic Trichothecenes from Extracts of Filamentous Fungi through UV and NMR Profiles.
Arlene A. Sy-Cordero, Tyler N. Graf, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, and Nicholas H. Oberlies
Journal of Antibiotics, 2010, 63, 539-544.
PMID:20648023; PMCID: PMC2946446; doi: 10.1038/ja.2010.77

Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Constituents and Preliminary Structure-Activity Relationships.
Arlene Sy-Cordero, Tyler N. Graf, Yuka Nakanishi, Mansukh C. Wani, Rajesh Agarwal, David J. Kroll, and Nicholas H. Oberlies
Planta Medica, 2010, 76, 644-647.
PMID:19941262; PMCID: PMC2910627; doi: 10.1055/s-0029-1240624

Identification of Hepatoprotective Flavonolignans from Silymarin.
Stephen J. Polyak, Chihiro Morishima, Volker Lohmann, Sampa Pal, David Y. W. Lee, Yanze Liue, Tyler N. Graf, and Nicholas H. Oberlies
Proceedings of the National Academy of Sciences USA, 2010, 107, 5995-5999.
PMID: 20231449; PMCID: PMC2851903; doi: 10.1073/pnas.0914009107

Silymarin Inhibits in Vitro T Cell Proliferation and Cytokine Production in Hepatitis C Virus Infection.
Chihiro Morishima, Margaret C. Shuhart, Chia C. Wang, Denise M. Paschal, Minjun C. Apodaca, Yanze Liu, Derek D. Sloan, Tyler N. Graf, Nicholas H. Oberlies, David Y.–W. Lee, Keith R. Jerome, and Stephen J. Polyak
Gastroenterology, 2010, 138, 671-681.
PMID:19782083; PMCID: PMC2819600; doi: 10.1053/j.gastro.2009.09.021

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.
Huffman JW, Hepburn SA, Reggio PH, Hurst DP, Wiley JL, Martin BR.
Bioorg Med Chem., 2010 Aug 1;18(15):5475-82.
PMID: 20621488; PMCID: PMC2920039; doi: 10.1016/j.bmc.2010.06.054

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.
Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH.
J Biol Chem., 2010 Jun 4;285(23):17954-64.
PMID: 20220143; PMCID: PMC2878557; doi: 10.1074/jbc.M109.041590

2009

Identification of a Cranberry Juice Product That Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans.
Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies, and Mary F. Paine
Drug Metabolism and Disposition, 2009, 37, 514-522.
PMID: 19114462; PMCID: PMC2650736; doi: 10.1124/dmd.108.024968

Bioactive Constituents of the Stem Bark of Mitrephora Glabra.
Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, III Joseph O. Falkinham III, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, and Nicholas H. Oberlies
Journal of Natural Products, 2009, 72, 1949-1953.
PMID: 19874044; PMCID: PMC2862477; doi: 10.1021/np900572g

Discovery of Anticancer Agents of Diverse Natural Origin.
A. Douglas Kinghorn, Esperanza J. Carcache de Blanco, Hee-Byung Chai, Jimmy Orjala, Norman R. Farnsworth, D. Doel Soejarto, Nicholas H. Oberlies, Mansukh C. Wani, David J. Kroll, Cedric J. Pearce, Steven M. Swanson, Robert A. Kramer, William C. Rose, Craig R. Fairchild, Gregory D. Vite, Stuart Emanuel, David Jarjoura, and Frederick O. Cope
Pure Applied Chemistry, 2009, 81, 1051-1063.
PMID: 20046887; PMCID: PMC2765058; doi: 10.1351/PAC-CON-08-10-16

Role for PPAR <gamma> in IL-2 inhibition in T cells by Echinacea-derived undeca-2E-ene-8,10- diynoic acid isobutylamide.
Kevin Spelman, Katrina Liams-Hauser, Nadja B. Cech, Ethan Will Taylor, Nicholas Smirnoff, and Cynthia A. Wenner.
International Immunopharmacology, 91260-1264
PMID:19712756; doi: 10.1016/j.intimp.2009.08.009

2008

Residues accessible in the binding-site crevice of transmembrane helix 6 of the CB2 cannabinoid receptor.
Nebane NM, Hurst DP, Carrasquer CA, Qiao Z, Reggio PH, Song ZH.
Biochemistry., 2008 Dec 30;47(52):13811-21.
PMID: 19053233; PMCID: PMC4791095; doi: 10.1021/bi8007802

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.
Pei Y, Mercier RW, Anday JK, Thakur GA, Zvonok AM, Hurst D, Reggio PH, Janero DR, Makriyannis A.
Chem Biol. 2008 Nov 24;15(11):1207-19
PMID: 19022181 PMCID:PMC3700404 doi: 10.1016/j.chembiol.2008.10.011

Conformational memories with variable bond angles.
Whitnell RM, Hurst DP, Reggio PH, Guarnieri F.
J Comput Chem., 2008 Apr 15;29(5):741-52.
PMID: 17876759

2007

Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME.
J Biol Chem., 2007 Aug 24;282(34):25100-13.
PMID: 17595161

Mutation studies of Ser7.39 and Ser2.60 in the human CB1 cannabinoid receptor: evidence for a serine-induced bend in CB1 transmembrane helix 7. Mol Pharmacol.
Kapur A, Hurst DP, Fleischer D, Whitnell R, Thakur GA, Makriyannis A, Reggio PH, Abood ME.
Mol Pharmacol., 2007 Jun;71(6):1512-24.
PMID: 17384224; doi: 10.1124/mol.107.034645

2005

A Hexacyclic Ent-Trachylobane Diterpenoid Possessing an Oxetane Ring from Mitrephora Glabra.
Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Jason P. Burgess, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham III, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, and Nicholas H. Oberlies
Organic Letters, 2005, 7, 5709-5712.
PMID: 16321028; PMCID: PMC2442714; doi: 10.1021/ol052498l

Diterpene Glycosides from Egletes viscosa.
Dongho Lee, Chen Li, Tyler N. Graf, Jose Schunke Vigo, James G. Graham, Fernando Cabieses, Norman R. Farnsworth, Geoffrey A. Cordell, A. Douglas Kinghorn, David J. Kroll, Mansukh C. Wani, and Nicholas H. Oberlies
Planta Medica, 2005, 71, 792-794.
PMID: 16142652; doi: 10.1055/s-2005-871227

Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells.
Paula R. Davis-Searles, Yuka Nakanishi, Nam-Cheol Kim, Tyler N. Graf, Nicholas H. Oberlies, Mansukh C. Wani, Monroe E. Wall, Rajesh Agarwal, and David J. Kroll
Cancer Research, 2005, 65, 4448-4457.
PMID: 15899838; doi: 10.1158/0008-5472.CAN-04-4662

(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor.
Picone RP, Khanolkar AD, Xu W, Ayotte LA, Thakur GA, Hurst DP, Abood ME, Reggio PH, Fournier DJ, Makriyannis A.
Mol Pharmacol., 2005 Dec;68(6):1623-35.
PMID: 16157695; doi: 10.1124/mol.105.014407

Adamantyl cannabinoids: a novel class of cannabinergic ligands.
Lu D, Meng Z, Thakur GA, Fan P, Steed J, Tartal CL, Hurst DP, Reggio PH, Deschamps JR, Parrish DA, George C, Järbe TU, Lamb RJ, Makriyannis A.
J Med Chem., 2005 Jul 14;48(14):4576-85.
PMID: 15999995; doi: 10.1021/jm058175c

Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template.
Zhang R, Hurst DP, Barnett-Norris J, Reggio PH, Song ZH.
Mol Pharmacol., 2005 Jul;68(1):69-83.
PMID: 15840841; doi: 10.1124/mol.104.007823

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR.
Bioorg Med Chem., 2005 Jan 3;13(1):89-112.
PMID: 15582455; doi: 10.1016/j.bmc.2004.09.050

2004

Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia.
Jian-Qiao Gu, Tyler N. Graf, Dongho Lee, Hee-Byung Chai, Qiuwen Mi, Leonardus B. S. Kardono, Fransisca M. Setyowati, Rachman Ismail, Soedarsono Riswan, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, Steven M. Swanson, David J. Kroll, Joseph O. Falkinham III, Monroe E. Wall, Mansukh C. Wani, A. Douglas Kinghorn, and Nicholas H. Oberlies
Journal of Natural Products, 2004, 67, 1156-1161.
PMID: 15270571; doi: 10.1021/np040027m

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.
McAllister SD, Hurst DP, Barnett-Norris J, Lynch D, Reggio PH, Abood ME.
J Biol Chem., 2004 Nov 12;279(46):48024-37.
PMID: 15326174; doi: 10.1074/jbc.M406648200

An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region.
McAllister SD, Rizvi G, Anavi-Goffer S, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Abood ME.
J Med Chem., 2003 Nov 20;46(24):5139-52.
PMID: 14613317; doi: 10.1021/jm0302647

-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor.
Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR.
Bioorg Med Chem., 2003 Feb 20;11(4):539-49.
PMID: 12538019

2002

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.
Singh R, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Guarnieri F.
J Pept Res., 2002 Dec;60(6):357-70.
PMID: 12464114

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.
Hurst DP, Lynch DL, Barnett-Norris J, Hyatt SM, Seltzman HH, Zhong M, Song ZH, Nie J, Lewis D, Reggio PH.
Mol Pharmacol., 2002 Dec;62(6):1274-87.
PMID: 12435794

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.
Barnett-Norris J, Hurst DP, Lynch DL, Guarnieri F, Makriyannis A, Reggio PH.
J Med Chem., 2002 Aug 15;45(17):3649-59.
PMID: 12166938

A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition.
McAllister SD, Tao Q, Barnett-Norris J, Buehner K, Hurst DP, Guarnieri F, Reggio PH, Nowell Harmon KW, Cabral GA, Abood ME.
Biochem Pharmacol., 2002 Jun 15;63(12):2121-36.
PMID: 12110371

1999

The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2).
Song ZH, Slowey CA, Hurst DP, Reggio PH.
Mol Pharmacol., 1999 Oct;56(4):834-40.
PMID: 10496968

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.
Tao Q, McAllister SD, Andreassi J, Nowell KW, Cabral GA, Hurst DP, Bachtel K, Ekman MC, Reggio PH, Abood ME.
Mol Pharmacol., 1999 Mar;55(3):605-13.
PMID: 10051546

1998

The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Reggio PH, Basu-Dutt S, Barnett-Norris J, Castro MT, Hurst DP, Seltzman HH, Roche MJ, Gilliam AF, Thomas BF, Stevenson LA, Pertwee RG, Abood ME.
J Med Chem. 1998 Dec 17;41(26):5177-87.
PMID: 9857088

Exploration of biologically relevant conformations of anandamide, 2-arachidonylglycerol, and their analogues using conformational memories.
Barnett-Norris J, Guarnieri F, Hurst DP, Reggio PH.
J Med Chem., 1998 Nov 19;41(24):4861-72.
PMID: 9822555